The appearance of the effects of CYGB-deletion on hepatocytes but not on HSCs
was unexpected, because HSCs
had been considered to be the sole cell type that expresses CYGB in the liver.
Thus, our results demonstrate the 2.2-kb hGFAP gene promoter holds matched regulatory elements therefore is capable of introducing specific expression of transgene in porcine HSCs
and PSCs, providing a novel strategy to selectively manipulate the HSCs
and PSCs in a large animal model.
HIV infection of the gastrointestinal tract leads to an increase in lipopolysaccharide (LPS) which can stimulate hepatocytes, KCs and HSCs
to produce pro-inflammatory cytokines and chemokines which attract activated lymphocytes and monocytes to the liver which may further drive fibrosis.
Moreover, TLR4 signaling in both immune cells (i.e., Kupffer cells) and nonimmune cells involved in tissue repair (i.e., HSCs
) is required for the development of alcoholic hepatitis and fibrosis (Inokuchi et al.
are the major cell type involved in liver fibrosis which is the formation of scar tissue in response to liver damage.
A patient's HSCs
are collected and removed from the body through a process called apheresis.
In hemophagocytic lymphohistiocytosis, a systemic inflammatory disorder characterized by phagocytosis of HSCs
, these target cells were found to express reduced levels of CD47 (16).
Harvesting effective donor HSCs
can be a challenge.
For patients with certain forms of leukemia, the only chance they have for a cure is to receive a massive dose of radiation and chemotherapy that kills their hematopoietic stem cells (HSCs
), the cells responsible for making new blood, and then receive new HSCs
from a healthy donor.
In the quiescent state, HSCs
are known as quiescent HSCs
(qHSCs), and they are responsible for the storage of vitamin A in the liver.
Hematopoietic stem cells (HSCs
) have an ability to multipotency and self-renewing.
Hepatic stellate cells (HSCs
) play an important role as a central component in the fibrosis process induced by alcohol consumption.