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Putative miRNA binding sites were identified in in each of the seven human corticosteroidogenic genes (CYP11B1, CYP11B2, CYP11A1, CYP17A1, CYP21A2, HSD3B2, and StAR) and in the two metabolising genes (HSD11B1, HSD11B2) analysed (Table 2).
Interestingly, the dehydrogenase enzymes were not affected; the HSD11B1 and HSD11B2 products control the interconversion of cortisol and cortisone in many target tissues, but their mRNA levels were unaffected by Dicer1 knockdown.
Relative mRNA abundance of the G6pc (a), Pck1 (b), Acaca (c), Fasn (d), Scd1 (e), Hsd11b1 (g), and Hsd11b2 (h) genes in the liver tissue from either C57BL/6J mice fed either Western diet for 20 weeks (black panels) or 14-week-old db/db mice (gray panels).
The report provides comprehensive information on the Corticosteroid 11-Beta-Dehydrogenase Isozyme 1 (11-Beta-Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or 11-DH or 11-beta-HSD1 or HSD11B1 or EC 188.8.131.52), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
* The report provides a snapshot of the global therapeutic landscape for Corticosteroid 11-Beta-Dehydrogenase Isozyme 1 (11-Beta-Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or 11-DH or 11-beta-HSD1 or HSD11B1 or EC 184.108.40.206)
HSD11B1, HSD11B2, PTGS2 and NR3C1expression in the peri-implantation ovine uterus: effects of pregnancy,progesterone and interferon tau.
De los 17 genes restantes asociados al fenotipo HLFC contenidos en el modulo URFA, tres de ellos tienen funciones conocidas en el metabolismo lipidico (ABCC6, AKT2, HSD11B1) y uno mas que puede estar relacionado por su homologia con otra enzima (PNPLA4).
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