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Next, the cells were treated with 0.01, 0.1, 1, 10, or 100 [micro]M Escherichia coli LPS (13) or 1, 5, or 10 [micro]M HSP60 (14).
In the hsp60-based neighbor-joining tree comprising 52 representative reference and type strains (online Technical Appendix Figure 1), the sequences of C47 and C308 co-localized with hsp60 cluster III and that of C309 localized with hsp60 cluster VIII; both had [greater than or equal to] 99.3% identity within the clusters.
* Under normal physiological conditions, HSP60 is not expressed on vascular EC surfaces.
HSP60 is recognized as chaperon protein preventing acinar cells from damage .
P277 is a peptide derived from HSP60, vaccines based on this peptide were under phase III clinical trials, and the existing studies show it is a well-tolerated and effective vaccine in T1DM .
When present, abnormally enlarged inclusions (AB) detected by electron microscopy or Hsp60 antibody detected by serological testing indicate Ct-persistent infection.
Each Hsp subfamily has a different mechanism of action, some of them cause the degradation of misfolded proteins, some prevent the aggregation of Hsps by binding to different intermediates of folding (Hsp70 and Hsp60) and Hsp100 re-activates the already aggregated proteins.
(Hsp60 levels in saliva of patients with periodontal disease).
Mammalian HSPs have been classified into five families according to their molecular size: HSPlOO, HSP90, HSP70, HSP60, and small HSPs.
In a more recent study, intrathecally injected HSP60 injured neuronal cells and oligodendrocytes in the CNS, whereas mice lacking TLR4 and MyD88 (TLR4 adaptor molecule) are found to be protective against deleterious effects of HSP60 .
Additionally, heat shock protein 60 (Hsp60), a mitochondrial chaperonin involved in stress responses, diabetes, and immunological disorder, has structural similarity to thyroglobulin and thyroid peroxidase molecules.
In eukaryotes, HSPs are a large and heterogeneous group of proteins that have been classified into families based on their molecular weight: Hsp40, Hsp60, Hsp70, Hsp90, Hsp100, and the small HSPs .
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- HSP 17
- Hsp 27
- Hsp 27
- HSP 84
- HSP 86
- HSP 90
- hsp70 RY
- HSP70-like protein 1
- HSP90 beta
- Hsp90 heat-shock proteins