Three pivotal trials have looked at the addition of docetaxel to first-line ADT for the treatment of metastatic HSPC
. In the first reported trial, GETUG-AFU15, 385 men with metastatic HSPC
were randomized to ADT alone or ADT plus docetaxel 75mg/[m.sup.2] every three weeks for up to nine cycles.
The core material of Lipoid S 75 had greater efficiency and a smaller particle size (62.81 [+ or -] 1.37 nm) when compared to other core materials of Lipoid S 75-3 (171.60 [+ or -] 4.54 nm), Lipoid S 100 (72.67 [+ or -] 1.31 nm), Lipoid S 100-3 (156.60 [+ or -] 3.51 nm), Lecinol S 10 (162.36 [+ or -] 5.45 nm), and HSPC
50 (158.57 [+ or -] 4.54 nm) (Figure 1).
As part of Pfizer and Astellas' ongoing commitment to the clinical development of enzalutamide, Xtandi is also being evaluated in the EMBARK trial, in men with high-risk non-metastatic HSPC
ARCHES is a randomised Phase 3 study evaluating the efficacy and safety of enzalutamide plus androgen deprivation therapy (ADT) versus ADT alone in metastatic HSPC
Recent findings contributed to highlight how HSPC
fate could be dictated by inflammatory factors in the BM microenvironment as HSPCs
may actively respond to danger signals and proinflammatory cytokines [4, 5].
In coculture system, adipocytes arrest HSPCs
in the G0 phase of the cell cycle and induce apoptosis of HSPCs
The ROS levels of [LSK.sup.+] cells significantly increased in the Fe mice compared to the control group (P<0.05), whereas DFX or NAC treatment significantly inhibited the production of ROS in iron overloaded HSPC
compared to the Fe group (P<0.05, Figure 4).
manager Sarah Woodcock said: "The NC500 is a great way to showcase the Highlands as an amazing place to live.
(3) Liposomes composed of HSPC
: chol = 70 : 30 and HSPC
: chol: DSPE-PEG2k-Mal-GE11 = 68.6: 29.4 : 2 were prepared with the above method and were purified with dialysis to eliminate the D-luciferin that had not been encapsulated.
Liposomes were prepared by the evaporation method using different molar ratios of HSPC
:Chol:DSPE-PEG2000 (e.g., 50:45:5) (Dr.
The number of hematopoietic stem and progenitor cells (HSPC
) mobilized by granulocyte colony-stimulating factor was dramatically reduced in 6-OHDA-lesioned mice .
As such, a new nomenclature was developed where DNAJ, HSPD, HSPA, HSPC
, HSPH, and HSPB are the preferred prefix terms for the Hsp40, Hsp60, Hsp70, Hsp90, Hsp100, and small Hsp family members, respectively .