Three pivotal trials have looked at the addition of docetaxel to first-line ADT for the treatment of metastatic
HSPC. In the first reported trial, GETUG-AFU15, 385 men with metastatic
HSPC were randomized to ADT alone or ADT plus docetaxel 75mg/[m.sup.2] every three weeks for up to nine cycles.
The core material of Lipoid S 75 had greater efficiency and a smaller particle size (62.81 [+ or -] 1.37 nm) when compared to other core materials of Lipoid S 75-3 (171.60 [+ or -] 4.54 nm), Lipoid S 100 (72.67 [+ or -] 1.31 nm), Lipoid S 100-3 (156.60 [+ or -] 3.51 nm), Lecinol S 10 (162.36 [+ or -] 5.45 nm), and
HSPC 50 (158.57 [+ or -] 4.54 nm) (Figure 1).
As part of Pfizer and Astellas' ongoing commitment to the clinical development of enzalutamide, Xtandi is also being evaluated in the EMBARK trial, in men with high-risk non-metastatic
HSPC.
ARCHES is a randomised Phase 3 study evaluating the efficacy and safety of enzalutamide plus androgen deprivation therapy (ADT) versus ADT alone in metastatic
HSPC patients.
Recent findings contributed to highlight how
HSPC fate could be dictated by inflammatory factors in the BM microenvironment as
HSPCs may actively respond to danger signals and proinflammatory cytokines [4, 5].
In coculture system, adipocytes arrest
HSPCs in the G0 phase of the cell cycle and induce apoptosis of
HSPCs.
The ROS levels of [LSK.sup.+] cells significantly increased in the Fe mice compared to the control group (P<0.05), whereas DFX or NAC treatment significantly inhibited the production of ROS in iron overloaded
HSPC compared to the Fe group (P<0.05, Figure 4).
HSPC manager Sarah Woodcock said: "The NC500 is a great way to showcase the Highlands as an amazing place to live.
(3) Liposomes composed of
HSPC : chol = 70 : 30 and
HSPC: chol: DSPE-PEG2k-Mal-GE11 = 68.6: 29.4 : 2 were prepared with the above method and were purified with dialysis to eliminate the D-luciferin that had not been encapsulated.
Liposomes were prepared by the evaporation method using different molar ratios of
HSPC:Chol:DSPE-PEG2000 (e.g., 50:45:5) (Dr.
The number of hematopoietic stem and progenitor cells (
HSPC) mobilized by granulocyte colony-stimulating factor was dramatically reduced in 6-OHDA-lesioned mice [38].
As such, a new nomenclature was developed where DNAJ, HSPD, HSPA,
HSPC, HSPH, and HSPB are the preferred prefix terms for the Hsp40, Hsp60, Hsp70, Hsp90, Hsp100, and small Hsp family members, respectively [21].