HSPGHeparan Sulfate Proteoglycan
HSPGHoward Smith Paper Group (UK)
HSPGHeparan Sulphate Proteoglycan Surface
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(A1, A4, B48, B100, E = apoproteins; ABCA1 and ABCG5/G8 = ATP-binding casette transporter proteins; CE = cholesterol ester; CETP = cholesterol ester transfer protein; CM = chylomicron; FA = fatty acid; HSPG = heparan sulphate proteoglycans; HDL = high-density lipoprotein; IDL = intermediate-density lipoprotein; LCAT = lecithin: cholesterol acyl transferase; LPL = lipoprotein lipase; LDL = low-density lipoprotein; LDLR = LDL receptor; LDLRP = LDL receptor-like protein; NEFA = non- esterified fatty acid; SR = scavenger receptor B1; UC = unesterified cholesterol; VLDL = very low-density lipoprotein.)
FGFR1 requires both HSPG as a co-receptor and Anosmin-1, which is also HSPG-associated.
[55] studied the role of perlecan, a dominant HSPG found in the subendothelial matrix of the vessel wall, in atherosclerosis development and progression in [E.sub.0] mice.
[sup][3],[4] Human sulfatase 1 (Hsulf-1) is a recently characterized endosulfatase that selectively removes sulfate groups from heparan sulfate proteoglycans (HSPG), thereby altering the binding sites on HSPG for signaling molecules.
Yapilan calismalarda heparinin PKE'nin temelini olusturan HSPG kaybini tamamen karsiladigi, ayrica hem IFN [gamma] hem de TNF [alpha]'ya baglayarak bunlari etkisizlestirdigi gosterilmistir.
The analysis of methods used for mechanical processing of the wheelset showed that the high-speed profile grinding (HSPG) process method was the most preferable one in the restoration of the roll profile of the repaired wheelset.
The researchers hypothesized that the SEVI fibrils bind target cells by interacting with cell-surface HSPG, naturally occurring anionic carbohydrate polymers with a structure that is closely related to heparin sulfate.
Proteoglycans heparin and chondroitin sulphate (HSPG and CSPG) are abundantly expressed on BMECs.
The following stock solutions of ECM-molecules were used for coating: 50 [micro]l collagen IV (collagen IV (0.5 mg/ml) in 0.25% acetic acid), 10 [micro]l laminin and 1 [micro]l heparan sulphate proteoglycan (HSPG) were added to 1 ml PBS in each culture dish and incubated at 34 [degrees]C for 24 h.
Additionally, apo E 1) is associated with transport of cholesterol ester in plasma and with the redistribution of cholesterol in tissues; 2) is a major protein constituent of TG rich lipoproteins, including chylomicrons, VLDL, and their remnants; and 3) serves as a high-affinity ligand for several hepatic lipoprotein receptors, including LDL-R and LDL receptor-related protein, and for cell surface heparin sulfate proteoglycan (HSPG).
Syndecan-1 (SDC-1) is a transmembrane heparan sulfate proteoglycan (HSPG).
ApoA5 induces a clearance of VLDL from the plasma through electrostatic interactions with heparin sulfate proteoglycan (HSPG).