HSROC

AcronymDefinition
HSROCHierarchical Summary Receiver Operating Characteristic
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The HSROC curves showed better sensitivity (94% (95% CI 78-98) for MB and 56% (95% CI 17-81) for PB) and specificity (99% (95% CI 97-100)) for the ND-O-BSA antigen.
An HSROC plot displaying diagnostic accuracy results of the included studies by antigen in ELISAs: (A) PGL-I, (B) ND-O-BSA, and (C) LID-1 for different leprosy patient groups (MB and PB).
Summary points of the HSROC curve accuracy for each M.
Figures 4-6 showed the forest plot of the sensitivity, specificity, diagnostic odds ratio, LR+, and LR-, and the SROC and HSROC plot were presented in Figure 7 and Figure 8, respectively.
We found a strong threshold effect among studies; therefore, the HSROC model was enrolled in the present study for pooled analyses, which jointly summarize pooled sensitivity and specificity while taking into account the threshold effect.
Although we used a HSROC model in our analysis, our conclusion should be interpreted with caution.
Caption: Figure 8: HSROC of the monofilament test for detecting DPN.
Hemos ajustado cuatro modelos HSROC con distintas especificaciones; no son mas que casos particulares de este modelo general:
Sin embargo, dos estudios con el mismo tamano total pueden tener diferentes porcentajes de las poblaciones de T y N (los modelos NB y HSROC superan esta dificultad, incluyendo el tamano especifico de cada grupo, [N.sub.T] y [N.sub.N]).
Los metodos NB y HSROC son los mas adecuados para realizar meta-analisis de estudios de clasificacion binaria, especialmente para instrumentos diagnosticos.
Por el contrario, como el procedimiento HSROC modela directamente la precision y el umbral, se pueden incorporar covariables explicativas de ellos, pero S y E quedan determinados.