HSV-TK

AcronymDefinition
HSV-TKHerpes Simplex Virus Thymidine Kinase Gene
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References in periodicals archive ?
Cells including targeted chromosome 21 were killed in this selection medium because of HSV-tk genes present in the target fragment.
Therefore, extra copies of chromosome 21 integrating the DNA cassette may tend to be lost from the HeLa cells spontaneously under condition in which cells including HSV-tk gene are excluded.
Engineering of Systematic Elimination of a Targeted Chromosome in Human Cells
Aguilar-Cordova et al., "Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with recurrent malignant brain tumors," Molecular Therapy, vol.
Gene therapy with HSV1-sr39TK/GCV exhibits a stronger therapeutic efficacy than HSV1-TK/GCV in rat C6 glioma cells
Construction of retroviral vector and determination of retroviral titre: After confirming orientation ofthe HSV-tk gene cloned in pLTKSN it was co-transfected into 293 cells with an ecotropic helper virus pEcoLandau to produce ecotropic viral particles.
Effect of suicide gene therapy in combination with immunotherapy on antitumour immune response & tumour regression in a xenograft mouse model for head & neck squamous cell carcinoma
The clinical trials have confirmed that the HSV-TK gene therapy was superior to conventional treatments in the primary endpoints, especially in survival rates.
Takara Bio, MolMed Announce That Phase I/II Clinical Trial of HSV-TK Gene Therapy Delivers Positive Results
The Shiga Prefecture-based Takara Bio, a subsidiary of Takara Holdings Inc., expects the techniques to draw a total of about 45,000 latent patients, with 20,000 for treatment with HSV-TK gene, another 20,000 for HSV-TK-MAGE3 genes and 5,000 for AIDS.
Takara Bio to commercialize 3 gene therapy techniques in Asia
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