HSV1-TKHerpes Simple Virus type 1 Thymidine Kinase
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References in periodicals archive ?
Gambhir, "PET imaging of herpes simplex virus type 1 thymidine kinase (HSV1-tk) or mutant HSV1-sr39tk reporter gene expression in mice and humans using [[sup.18]F]FHBG," Nature Protocols, vol.
Forty-eight hours after the addition of DNA-liposome complex, immunocytochemistry analysis demonstrated a heterogeneous HSV1-TK expression in both C6-TK and C6-sr39TK cells (Figure 1), whereas no positive cell was found in control C6 cells.
This band corresponds to the predicted molecular weight of HSV1-TK and HSV1-sr39TK, while the control C6 cells had no similar bands.
The most widely used gene therapy approach is the transfection of suicide gene, such as the HSV1-TK/GCV system [19-23], in which GCV is first phosphorylated by HSV1-TK to its monophosphates (GCV-MP) and further phosphorylated by cellular kinase to its triphosphates (GcV-TP).