HTOR5-@hydroxytryptamine Oxygenase Regulator
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In brief, a final 100 [micro]L of incubation mixtures containing pooled HLMs (0.1 mg/ml), AST (1 [micro]M) and inhibitor (HEB (positive control), TAM, HTAM, TOR, HTOR, GSK5182, or HGSK5182 (5 [micro]M)) were pre-incubated for 5 min at 37[degrees]C.
Based on these data, we underwent to test the inhibitory effect of HTOR on CYP2J2-mediated astemizole O-demethylation activity.
Its application here to the heart (htor) seems unique.