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However, all interferon [alpha]/[beta] receptor knockout mice (IFNAR -/-) inoculated with SFTSV died within 3-4 dpi and showed marked SFTSV antigen expression and increased viremia profiles than did wild-type mice of the same genetic background (19,20), which is consistent with our results for Ag129 mice experimentally inoculated with HTRV (20).
Similar to pathologic changes reported for SFTSV infection in C57BL/6 mice (19) and IFNAR knockout mice (20), viremia and major pathologic changes developed in Ag129 mice inoculated with HTRV, which is consistent with platelet depletion and subsequent thrombocytopenia.