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To overcome this obstacle, we have continued to culture DE in vitro for 10 days, which enabled the incorporated hUCMS to produce ECM bringing additional mechanical strength.
Currently, most of the studies related to MSCs in wound skin clinical treatments are related to BM-MSCs; only limited studies mentioned the application of hUCMS [25, 26].
hUCMS by their nature are low immunogenic and are able to mitigate the inflammatory environment of the wound by the secretion of various immunomodulatory molecules.
In addition, promotion of a tolerogenic environment results from the secretion of paracrine factors by hUCMS that could recall many cell types, including epithelial cells, endothelial cells, keratinocytes, and fibroblasts, and regulate a number of different cellular responses related to cell survival, proliferation, migration, and gene expression .
We think that in our case, this modulation depends on the ability of hUCMS to secrete ECM independently.
In fact, hUCMS seeded on fibrin scaffolds remain on the surface where they organize to form a multilayered structure, as evidenced by staining with H&E.
However, the obtained data indicate that the hUCMS are composed of multilayered and well-compacted cells, lacking well-recognizable layers of the differentiated skin.
Our data show that at 42 days in the subcutis of the graft area, hUCMS completely disappeared (lack of Ku80 expression) but there was a marked neogenesis of murine dermal annexes as hairs and glands instead.
A biomimetic scaffold consisting of hUCMS and fibrin (DE) is simple to fabricate, and it resembles the normal skin architecture.
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