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Abbreviations: ANA, antinuclear antibodies; HpCDD, heptachlorodibenzo-p-dioxin; HpCDF, heptachlorodibenzofuran; HxCDD, hexachlorodibenzo-p-dioxin; HxCDF, hexachlorodibenzofuran; LOD, limit of detection; OCDD, octachlorodibenzo-p-dioxin; OCDF, octachlorodibenzofuran; PCB, polychlorinated biphenyl; PnCDD, pentachlorodibenzo-p-dioxin; PnCDF, pentachlorodibenzofuran; TCDD, tetrachlorodibenzo-p-dioxin; TCDF, tetrachlorodibenzofuran; TEF, toxic equivalency factor.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin (HxCDD) alter body weight by decreasing insulin-like growth factor I (IGF-I) signaling.
In addition, because results near the limit of detection (LOD) are subject to greater uncertainty, we limited the analyses to chemicals that were detected in all participants for serum and milk [bromodiphenyl ether (BDE) 47 and 100; hexachlorobenzene (HCB); trans-nonachlor; 1,1 -dichloro-2,2-bis(p-chloro-phenyl)ethylene (p,p'-DDE); 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (p,p'-DDT); PCBs 74, 99, 118, 126, 138-158, 146, 153, 170, 180, and 187; 1,2,3,6,7,8-hexachIoro-dibenzo-p-dioxin (HxCDD); 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HpCDD); octachlorodibenzo-p-dioxin (OCDD); and 1,2,3,4,6,7,8-heptachlorodibenzofuran (HpCDF)].