HYVETHypertension in the Very Elderly Trial
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First, the mean age of patients in the HYVET treatment arm was 83.
However, patients with heart failure, elevated serum creatinine level, dementia, and a requirement of nursing care were excluded from the HYVET study.
Beckett NS, Peters R, Fletcher AE, Staessen JA, Liu L, Dumitrascu D, Stoyanovsky V, et al; HYVET Study Group.
Prior to the HYVET study, the treatment of hypertension in very elderly patients was not proven to be beneficial; the study showed unequivocally that initiation of treatment with indapamide, with or without perindopril vs.
Venkata Ram said the reduction in total mortality observed in HYVET was particularly reassuring, because earlier population studies have identified an increased risk of total mortality with hypertension control in the elderly.
In the HYVET trial, patients were randomized to placebo or indapamide SR 1.
A careful reading of the HYVET methods shows how difficult it is to do good research in the very elderly, but more importantly, the results show just how rewarding such meticulous work can be.
Patients in the HYVET study had a higher baseline blood pressure of 173/91 mm Hg, and the target blood pressure in the treatment group was 150/90 mm Hg.
HYVET showed that lowering blood pressure with standard medications can improve both length and quality of life, regardless of the age at which treatment starts.
Beckett NS, Peters R, Fletcher AE, et al, for the HYVET Study Group.
High blood pressure medication has been known to reduce the rate of stroke, but the HYVET study suggests that both incidence of stroke and survival rate were improved.