Eptinezumab treatment resulted in clinically meaningful improvements in Headache Impact
Test (HIT-6) scores in chronic migraine patients as early as Month 1 after treatment, which were maintained or further improved throughout the six-month study period, compared to placebo, which did not achieve a clinically meaningful improvement until Month 6.
In the PROMISE-2 trial for chronic migraine, impact scores as measured by the Headache Impact
Test were significantly elevated at baseline.
The remaining students indulged in mild-to-moderate form of exercise, infrequently. A study has shown that students who do not indulge in regular physical activity are at a risk of developing recurrent headaches. Another study concluded that exercise is an alternative to prophylactic treatment among migraineurs. A study conducted in the National Institute of Mental Health and Neurosciences, Karnataka, India, on patients with migraine, was found that patients who practiced yoga along with conventional therapy showed statistically significant reduction of headache impact
His analysis focused on changes in participants' scores on the six-item Headache Impact
Test, or HIT-6, a test that's well established as a sensitive indicator of headache-related disability.
Secondary endpoints consisted of four PROs: the Headache Impact
Test of migraine-related disability (HIT-6), the Work Productivity and Activity Impairment Questionnaire: Specific Health Problem (WPAI-SHP), the Patient Health Questionnaire-9 (PHQ-9), and a cutting edge, not yet fully validated instrument known as the Functional Impact of Migraine Questionnaire, or FIMQ.
To assess disability, validated questionnaires such as the Headache Impact
Test (HIT-6) or the Migraine Disability Assessment Questionnaire (MIDAS) may be used.
Patient volunteers were asked to answer the Headache Impact
Test (HIT-6) questionnaire, which was developed to assess how headaches influence the patients' daily activities and their capacity to function.
The headache impact
test and an 11-point verbal rating scale were applied to assess headache severity and intensity.
Compared with the diet low in omega-3 fatty acids, the diet high in omega-3 fatty acids produced a greater improvement in the mean Headache Impact
Test score (-7.5 vs.
Other patient-reported quality of life outcomes Pre-Botox At follow-up Headache Impact
Test-6 63.3 60.5 Pain Disability Index 24.3 21.2 European Quality of Life 0.74 0.77 5-Dimension index Note: Based on data from 429 chronic migraine patients.
Table 1: A sample of selected Patient Reported Outcome Measures Name Type Application Diabetes Health HRQoL Monitoring impact of Profile diabetes on (DHP-18) patient's life Headache Impact
Symptoms and Headache severity and Test[TM] functioning impact of treatment (HIT[TM]) evaluation Measure Yourself Symptoms and Any condition Medical functioning involving symptoms Outcome Profile (MYMOP-2) Patient Health Wellbeing Severity of depression Questionnaire-9 (psychological) (PHQ-9) Name Comments Diabetes Health License required (but free Profile for clinical use).
Several widely used and well-validated tests have been designed to measure the specific characteristics of headache and headache-related disability, including the Headache Disorders, 2nd Edition (ICHD-II), the Nine-Item Screener , the Headache Impact
Test (HIT-6) , and the Three-Item ID Migraine Screener .