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HMOXHeme Oxygenase
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Higher levels of oxidative stress induced by chronic consumption of repeatedly heated palm oil have been shown to reduce renal heme oxygenase (13, 32-33), which is supposed to have antioxidative effects.
Tonegawa, "Reduced stress defense in heme oxygenase 1-deficient cells," Proceedings of the National Academy of Sciences of the United States of America, vol.
Sodhi et al., "Heme oxygenase gene targeting to adipocytes attenuates adiposity and vascular dysfunction in mice fed a high-fat diet," Hypertension, vol.
Schipper, "Heme oxygenase expression in human central nervous system disorders," Free Radical Biology & Medicine, vol.
For heme degradation, three host proteins and one symbiont protein were identified as heme oxygenase (HO) (Fig.
Possible role of heme oxygenase and ferritin," Laboratory Investigation, vol.
Appleton, "Cerebral heme oxygenase 1 and 2 spatial distribution is modulated following injury from hypoxia-ischemia and middle cerebral artery occlusion in rats," Neuroscience Research, vol.
It would be a future interesting model to test the aspirin-induced proliferative ability of these particular cell lines and subsequently the inhibitory effect by the heme oxygenase inducers such as NBrT.
Specific primers for heme oxygenase (decycling) 1 (HO-1), NAD(P)H dehydrogenase [quinone] 1 (NQO1), glutamatecysteine ligase catalytic subunit (GCLC), glutamate-cysteine ligase regulatory subunit (GCLM), and nuclear factor (erythroid-derived 2)-like 2/NF E2-related factor (Nrf2) were designed, as well as primers for several housekeeping genes (see Supplementary Table 1 available online at https://doi.
Traverso et al., "Induction of heme oxygenase 1 in liver of spontaneously diabetic rats," Free Radical Research, vol.
Polaprezinc (Zinc L-carnosine) is a potent inducer of anti-oxidative stress enzyme, heme oxygenase (HO)-1 - a new mechanism of gastric mucosal protection.