(redirected from Heparin-Platelet Factor 4)
HPF4Heparin-Platelet Factor 4
HPF4Anti-Human Platelet Factor 4
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Currently available enzyme immunoassays for antibodies against heparin-platelet factor 4 complex allow for sensitive detection of HIT, and the gold standard serotonin-release assay may also be used under some circumstances.
HIT-Type 2 is a severe immune-mediated drug reaction caused by antibodies to the heparin-platelet factor 4 (PF4) complexes, which can occur in any patient exposed to heparin (Tang et al., 2005).
Heparin-induced thrombocytopenia is a distinctive drug-induced thrombocytopenia associated with heparin therapy, where antibodies are formed to heparin-platelet factor 4 complexes, leading to platelet aggregation, platelet microparticle formation, endothelial injury, and paradoxical thrombosis.
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