(redirected from Hereditary Prostate Cancer)
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References in periodicals archive ?
* Having multiple first-, second-, or third-degree relatives on the same side of the family with the same or related types of cancer--prostate, breast, ovarian, pancreatic, or colorectal--suggestive of hereditary prostate cancer, hereditary breast and ovarian cancer syndrome, or Lynch syndrome
Common causes of hereditary prostate cancer are germline BRCA1 or BRCA2 gene mutations, which can often be associated with a more aggressive form of prostate cancer.
For example, families with hereditary prostate cancers often carry genetic mutations in the region, or locus, encoding RNase L.
Prostate cancer screening in high-risk men: African American Hereditary Prostate Cancer Study Network.
To learn more, contact: Hereditary Prostate Cancer Study, The Brady Urological Institute, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Marburg 130, Baltimore, MD 21287-2101.
"We have the largest registry of hereditary prostate cancer families in the world and have identified two genes that appear to explain the disease in some families.
Silverman has investigated RNase L for most of his careen Last year, he got an unexpected phone call from a group of geneticists who had been tracking down a hereditary prostate cancer gene on chromosome 1 since 1996.
Early age at diagnosis in families providing evidence of linkage to the hereditary prostate cancer locus (HPC1) on chromosome 1.
RNASEL - This gene is associated with hereditary prostate cancer and is associated with apoptosis (programmed cell death), inflammation and the ability of cells to proliferate and stick to each other (hallmarks of cancer growth).
Hereditary prostate cancer should be considered for families that present with multiple cases of prostate cancer and/or with early-onset prostate cancer (Walsh & Partin, 1997).
The African-American Hereditary Prostate Cancer Study is a collaborative effort between Howard University and the National Institutes of Health, and it's designed to determine if some members of African-American families have inherited alterations in their genetic material that contribute to an increased risk of developing prostate cancer.
black families included in the new study had the mutant gene, which the researchers have dubbed hereditary prostate cancer 1.
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