Abbreviations CVID: Common variable immunodeficiency DC: Dyskeratosis congenita GLILD: Granulomatous-lymphocytic interstitial lung disease HP1y: Heterochromatin protein 1
gamma IPF: Idiopathic pulmonary fibrosis PPFE: Pleuroparenchymal fibroelastosis TINF2: TRFFl-Interacting Nuclear Factor 2 UIP: Usual interstitial pneumonia.
Some senescent cell types are characterized by nuclear heterochromatin foci that can be visualized by DNA-stains and the increased expression of heterochromatin protein 1
gamma (HP1[gamma]) [28, 29].
TERMINAL FLOWER 2/LIKE HETEROCHROMATIN PROTEIN 1
(TFL2/LHP1), the Arabidopsis homologue of animal HP1, binds to histone H3K9me2 or H3K9me3 and to H3K27me3.
Human heterochromatin protein 1
isoforms HPl(Hsalpha) and HPl(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation.
The Ki-67 protein interacts with members of the heterochromatin protein 1
(HP1) family: a potential role in the regulation of higher-order chromatin structure.