Total colonic aganglionosis in Hirschsprung disease
The definitive finding that defines Hirschsprung disease
is absence of ganglion cells in the submucosal and myenteric plexuses in an adequate biopsy specimen of the rectum located more than 2 cm above the pectinate line.
Contrast enema revealed important gas distension of the colon, with a narrowing of the distal colon at less than half the normal diameter, with proximal dilation, the presence of a transition zone between sigmoid and descendent colon; important reduction of the rectum caliber, with filamentous ending, typical aspect for the Hirschsprung disease
, with rectosigmoid aganglionosis (Figure 1).
Can we stop looking: immunohistochemistry and the diagnosis of Hirschsprung disease
Evaluation of serosal nerves in Hirschsprung Disease
Highly recurrent RET mutations and novel mutations in genes of the receptor tyrosine kinase and endothelin receptor B pathways in Chinese patients with sporadic Hirschsprung disease
Testicular torsion, incarcerated hernia, intussusception, Hirschsprung disease
, appendici volvulus, bowel perforation.
Mutations of the RET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumours, and Hirschsprung disease
The results of the October 2001 review indicated "no evidence of Hirschsprung disease
He was diagnosed with Hirschsprung Disease
by doctors who said he had a blockage in his large intestine which had caused an infection.
Sometimes, difficulties with bowel movements are due to a single cause, including conditions such: as Hirschsprung disease
, tethered spinal cord, thyroid disease, a malformed, misplaced, or otherwise obstructed anus; a wide variety of medications; toxins such as lead; and dietary allergies, in particular to cow's milk.
During a three-day inquest at Bootle Town Hall, the jury heard how Miss Murray, a trainee hotel manager, had suffered from a rare bowel disorder known as Hirschsprung disease
since early childhood.