(redirected from Histamine H1 Receptor)
Also found in: Wikipedia.
H1RHistamine H1 Receptor (biology)
References in periodicals archive ?
Diphenhydramine is an inverse agonist of the histamine H1 receptor.
The results suggest that the efficacy of doxepin at low doses may be due in part to doxepin's selectivity for the histamine H1 receptor, and further suggest that histamine may be an integral part of a gating mechanism in the arousal system that allows transition from sleep to wake without residual sedation.
We attribute the drug's potential for weight management, particularly in obese women of child-bearing age, to its direct effect on the histamine H1 receptor system, which has demonstrates improved response in the presence of female hormones" said Nir Barak M.
Instead, the degree of sedation may be associated with each antipsychotic's affinity for the histamine H1 receptor, which is highly variable (Table 2, page 43).
The preclinical data found that lurasidone binds weakly to histamine H1 receptors, which have been implicated in weight gain and sedation, to the 5HT2C receptor, which has also been implicated in weight gain, and to muscarinic receptors, which might be involved in some of the cognitive effects associated with antipsychotics, said Dr.
We still do not have enough data on loratadine and other newer antihistamines to reach the same conclusion with certainty, however, even though these agents are members of the same class and presumably work on the same histamine H1 receptors.
4 nM, respectively), moderate affinity for dopamine D4, serotonin 5-HT2C and 5-HT7, alpha1-adrenergic and histamine H1 receptors (Ki values of 44, 15, 39, 57, and 61 nM, respectively), and moderate affinity for the serotonin reuptake site (Ki=98 nM).
Asenapine has high affinity for multiple dopamine, serotonin, noradrenergic [alpha]1 and [alpha]2, and histamine H1 receptors, where it works as an antagonist.