But a study presented at the annual Digestive Disease Week found significant upper GI events were much more common in patients who took famotidine (Protonix), a histamine-2 receptor
The results indicated that PPIs put patients at a significantly higher risk for pneumonia, although the increased risk from histamine-2 receptor
antagonists was not significant.
PubMed and Cochrane databases were searched for relevant articles using keyword and text word search including stress ulcer, stress-related mucosal disease, burn injury, Curling's ulcer, upper gastrointestinal bleeding, proton pump inhibitor, histamine-2 receptor
antagonist, pneumonia, burns and early enteral feeding.
Proton pump inhibitors and histamine-2 receptor
antagonists are associated with hip fractures among at-risk patients.
One audience member observed that some patients with hiatal hernia never receive the formal diagnosis, but instead are told they have reflux and put on a histamine-2 receptor
antagonists (H2 blockers), which include over-the-counter and prescription cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid) and ranitidine (Zantac).
As the Clinical Inquiry authors summarized, there are no adequate studies comparing the efficacy of PPIs in this role to either histamine-2 receptor
antagonists (H2RAs) or antacids.
Use of a PPI, a double-dose histamine-2 receptor
antagonist, or misoprostol along with an NSAID reduced the risk of peptic ulcer hospitalization by 39%.
antagonist therapy (eg, ranitidine, cimetidine) did not significantly increase hip fracture risk.
Maintenance medication requirements for GERD will vary between patients, but studies on the use of full-dose histamine-2 receptor
blockers once daily and reduced doses of PPI have shown them to be ineffective.
Medical therapy included supportive care, ICU monitoring, and acid suppressive medications, such as histamine-2 receptor
antagonists or proton-pump inhibitors.