Compared with the histo-blood group antigen
(HBGA) binding surface of strain SMV, the GII.2 strains in this study had 15 aa mutations in VP1, including 8 aa mutations at residues 335-349 around the HBGA binding site I in the P2 domain, although the conserved set of residues (Asn352, Arg353, Asp382, and Gly445) required for binding the fucose moiety of HBGAs in SMV was unchanged.
"The question now is do different strains use other histo-blood group antigens in this way?" he said.
Larger populations of infected individuals need to be studied to determine if there is a clear association of these virus strains using histo-blood group antigens as a receptor," they said.
Cell attachment protein VP8 * of a human rotavirus specifically interacts with A-type histo-blood group antigen
Norwalk virus binds to histo-blood group antigens present on gastroduodenal epithelial cells of secretor individuals.
Norovirus and histo-blood group antigens: demonstration of a wide spectrum of strain specificities and classification of two major binding groups among multiple binding patterns.
Norovirus-host interaction: multi-selections by human histo-blood group antigens
. Trends Mi crobiol.
Noroviruses bind to human ABO, Lewis, and secretor histo-blood group antigens: identification of 4 distinct strain-specific patterns.
Association of histo-blood group antigens and susceptibility to norovirus infections.
In the past several years, increasing evidence has emerged that human noroviruses bind to histo-blood group antigens (HBGAs) (11).
Norovirus and its histo-blood group antigen receptors: an answer to a historical puzzle.
Viral particles bind specifically to digestive ducts (midgut, main and secondary ducts, and tubules) by carbohydrate structures with a terminal N-acetylgalactosamine residue in an [alpha] linkage (same binding site used for recognition of human histo-blood group antigens