HRR

(redirected from Homologous Recombination Repair)
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AcronymDefinition
HRRHenley Royal Regatta (England)
HRRHeat Release Rate
HRRHeart Rate Reserve
HRRHigh Range Resolution
HRRHomologous Recombination Repair (DNA)
HRRHeart Rate Recovery
HRRHospital Referral Region (various states)
HRRHuman Rights Report (Association of On-line Press Editors)
HRRHome Residency Requirement (US INS)
HRRHealth-Related Research
HRRHuman Resource Representative
HRRHousehold Response Rate (health surveys)
HRRHigh-Resolution Radar
HRRHierarchical Round Robin
HRRHigh Resolution Radar
HRRHardy-Rand-Rittler (color plates used in ophthalmology)
HRRHumanitarian Response Review
HRRHead Rice Recovery
HRRHockey Related Revenues
HRRHuman Research Roadmap (US NASA)
HRRHarmonic Rejection Ratio
HRRHöchstrichterliche Rechtsprechung (German: Jurisprudence of the Supreme Court)
HRRHigh Resolution Resistivity (geophysical exploration and characterization method)
HRRHigh Ridge Resources (exploration; various locations)
HRRHigh Ramp Rate
HRRHigh Risk Records
HRRHuman Race's Run (band)
HRRHealth Readiness Record (US DoD)
HRRHorizontal Refresh Rate
HRRHelicopter Rapid Refueling Procedures
HRRHealth Risk Review
HRRHeilig Rooms Rijk (Dutch: Holy Roman Empire)
HRRHigh Risk Requirement
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References in periodicals archive ?
United Kingdom-based AstraZeneca and United States-based MSD have revealed positive results from the Phase III PROfound trial of Lynparza (olaparib) in men with metastatic castration-resistant prostate cancer who have a homologous recombination repair gene mutation and have progressed on prior treatment with new hormonal anticancer treatments, it was reported yesterday.
Release date- 07082019 - AstraZeneca and Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced positive results from the Phase III PROfound trial of LYNPARZA 300 mg (two 150 mg tablets) twice daily in men with metastatic castration-resistant prostate cancer (mCRPC) who have a homologous recombination repair gene mutation (HRRm) and have failed prior treatment with new hormonal anticancer agents (second generation anti-androgen agent).
Lynparza (olaparib) is a first-in-class PARP inhibitor and the first targeted treatment to block DNA damage response (DDR) in cells/tumours harbouring a deficiency in homologous recombination repair (HRR), such as mutations in BRCA1 and/or BRCA2.
AstraZeneca (AZN) and Merck (MRK) announced results from the Phase 3 PROfound trial of Lynparza in men with metastatic castration-resistant prostate cancer - mCRPC - who have an homologous recombination repair gene mutation and have progressed on prior treatment with new hormonal anticancer treatments.
Homologous recombination repair ensures the damage removal with simultaneous exact reproduction of the original sequence of the modified DNA.
In mammalian cells, numerous predominant DNA repair mechanisms are well analyzed, such as direct repair, base excision repair (BER), nucleotide excision repair (NER), mismatch repair, homologous recombination repair (HR), and non-homologous end-joining repair (NHEJ) [11].
(15) In the setting of DNA damage, the homologous recombination repair pathway is activated for repair.
Bishop, "ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair," PLoS ONE, vol.
Polymorphisms in RAD51, [XRCC.sub.2] and [XRCC.sub.3] genes of the homologous recombination repair in colorectal cancer a case control study.
Homologous recombination repair of DSBs is essential for making error-free genetic information from a homologous undamaged DNA molecule.
Chen said the FANCI-FANCD2 pathway also is associated with the BRCA1 and BRCA2 pathways, which are involved in homologous recombination repair. Scientists know that homologous recombination repair is also required for the repair of DNA cross-links, but the exact details remain to be resolved, Chen said.