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Our recent study demonstrated NCL involvement in regulating IR-induced cardiac injury and dysfunction by upregulating Hsp32 expression. To expand on these findings and determine the specific functions of NCL in cardiocytes, we hypothesized that NCL regulated IR-induced cardiac injury and dysfunction by controlling the expression of miRNAs involved in posttranscriptional regulation of important genes in cardiocytes.
Studies in rat lung have shown that arsenite enhances the binding of AP-1 to DNA and induces stress protein expression, including heat-shock proteins HSP32 and HSP72 (Wijeweera et al.
Medical Compounds/ Dose/ Family names plants extracts duration Solanaceae Withania Withaferin A 2.5 [micro]M, somnifera 1 [micro]M for 24h Zingiberaceae Aframomum Methanol 40 [micro]g/mL arundinaceum extract for 72 h Clusiaceae Garcinia 8-Hydroxycudra- 22.49 [micro]M nobilis xanthone G, for 24h cudraxanthone I Moraceae Dorstenia Isobavachalcone 23.78 [micro]M barteri for 24h Target molecules and additional Cell Family names efficacy lines References Solanaceae [up arrow] ERK1/2, U87, U251,  HSP32, HSP70 T98G AKT, mTOR, p70 S6K, c-Met, EGFR, [down arrow] Her2, HSF1 Oxidative stress, heat shock response, AKT/mTOR pathway, MGMT Zingiberaceae Collateral U87MG.
Heme oxygenase (HO-1), also called heat shock protein 32 (hsp32), is an inducible enzyme catalyzed rate-limiting step in the oxidative degradation of heme to free iron, biliverdin, and carbon monoxide .
Heme oxygenase 1 (HO-1), also referred to as HSP32, belongs to the HSP family, and influence various biological events by degrading toxic heme into free iron, carbon monoxide, and biliverdin/bilirubin (Morse and Choi, 2002).
HO-1 is a 32 kDa member of the stress protein superfamily (HSP32).
Abrahamsson, "Expression of heme oxygenase-1 (HSP32) in human prostate: normal, hyperplastic, and tumor tissue distribution," Urology, vol.
Vitagenes include the genes coding for the heat shock proteins (HSP) such as Hsp32 (also called Heme oxygenase 1, HO-1) and Hsp70, sirtuins, and the thioredoxin/thioredoxin reductase systems.
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- HSP 17
- Hsp 27
- Hsp 27
- HSP 84
- HSP 86
- HSP 90
- hsp70 RY
- HSP70-like protein 1
- HSP90 beta