18) Studies have shown that oxidative DNA damage contributes to replicative cessation in human diploid fibroblast cells, but this process can be slowed with the use of antioxidants and spin-trapping agents such as alpha-phenyl-t-butyl nitrone (PBN), which can act like an antioxidant.
Oxidative DNA damage and senescence of human diploid fibroblast cells PNAS.
In this review, we summarize our recent studies on the effects of these mitochondrial metabolites and mitochondrial antioxidants (alpha-phenyl-N-t-butyl nitrone and N-tbutyl hydroxylamine) on the age-associated mitochondrial decay of the brain of old rats, neuronal cells, and human diploid fibroblast
Tocotrienol-rich fraction prevents cell cycle arrest and elongates telomere length in senescent human diploid fibroblasts
Human diploid fibroblasts
cultured under normal conditions have been reported to develop an irreversible cell cycle arrest, referred to as replicative senescence (Serrano and Blasco 2001).
We have examined the effects of the naturally occurring dipeptide carnosine (beta-alanyl-L-histidine) on the growth, morphology, and life span of cultured human diploid fibroblasts
However, arsenite disrupts normal mitotic progression and induces aneuploidy in human diploid fibroblasts
(Yih et al.
The results reveal a highly stereotypic pattern of response to IR in human diploid fibroblasts
that reflects primarily synchronization behind the [G.
Induction of DNA strand breaks by intermittent exposure to extremely-low-frequency electromagnetic fields in human diploid fibroblasts