(1) Maculopapular rash developing 3 weeks after starting with a limited number of drugs (2) Prolonged clinical symptoms 2 weeks after discontinuation of the causative drug (3) Fever ([greater than or equal to] 38[degrees]C) (4) Liver abnormalities (alanine aminotransferase > 100U-[L.sup.-1]) (a) (5) Leukocyte abnormalities (at least one present) (a) Leukocytosis ([greater than or equal to] 11 x [10.sup.9] [L.sup.-1]) (b) Atypical lymphocytosis ([greater than or equal to]5%) (c) Eosinophilia ([greater than or equal to]1.5 x [10.sup.9] [L.sup.-1]) (6) Lymphadenopathy (7) Human herpesvirus 6
reactivation The diagnosis is confirmed by the presence of the seven criteria above (typical DIHS) or of the first five (1-5) criteria (atypical DIHS).
Human herpesvirus 6
chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles.
(21.) Tohyama M, Hashimoto K, Yasukawa M, et al: Association of human herpesvirus 6
reactivation with the flaring and severity of drug-induced hypersensitivity syndrome.
Murovska, "Association of human herpesvirus 6
and human herpesvirus 7 with demyelinating diseases of the nervous system," Journal of NeuroVirology, vol.
Congenital infection with human herpesvirus 6
variante B associated with neonatal seizures and for neurological outcome.
CD46 is a cellular receptor for human herpesvirus 6
. Cell 1999; 99:817-827.
Pauschinger and his coworkers screened for a broader spectrum of cardiotropic viruses, including not only adenovirus and enterovirus but also parvovirus B19, human herpesvirus 6
, human cytomegalovirus, herpes simplex virus, Epstein-Barr virus, and influenzas A and B.
The peak age of acquisition of primary human herpesvirus 6
infection is between 9 and 21 months, according to results of a population-based study of 277 children followed from birth to 2 years.
On a related note, scientists studying human cell cultures have discovered that Human herpesvirus 6
(HHV-6) may influence the course of HIV infection by inhibiting "CCR5-tropic HIV," a type of HIV that is active during early infection.
A new polymerase chain reaction (PCR) technique helps to clarify the incidence of active human herpesvirus 6
(HHV-6) infection in recipients of autologous or allogeneic stem cells transplantation.
Some detected evidence of the roseola virus, or human herpesvirus 6
(HHV-6), in brain tissue taken from deceased multiple sclerosis patients.
(In Ortleb's view AIDS is caused by human herpesvirus 6
and closely associated with chronic fatigue syndrome.) The Native's readership declined from a high of 20,000 in 1985 to just 8,000 in 1996.