Human papillomavirus genotype specificity of hybrid capture 2
. J Clin Microbiol.
(a) ThinPrep (Hologic, Bedford, Massachusetts); SurePath (Becton, Dickinson and Company, Franklin Lakes, New Jersey); Digene (Qiagen, Gaithersburg, Maryland); Digene Hybrid Capture 2
(HC2; Qiagen, Gaithersburg, Maryland); Cervista (Hologic, Bedford, Massachusetts); cobas 4800 (Roche, Pleasanton, California); Gen-Probe Aptima (Hologic, Bedford, Massachusetts).
Com-parison of clinical performance of Abbott RealTime High Risk HPV test with that of Hybrid Capture 2
assay in a screening setting.
The last FDA-cleared molecular assay discussed in this article, will be the Hybrid Capture 2
High-Risk HPV DNA test by Qiagen, Inc.
Presently, the two assays most widely used for the detection of genital types are PCR with generic primers and the Hybrid Capture 2
assay (Digene Corp, Gaithersburg, MD, USA).
Aetna covers HPV DNA testing for patients with atypical squamous cells of undetermined significance using the Hybrid Capture 2
technique, and the insurer's clinical poli cy council will consider the information submitted to the FDA on the use of the test as a screening device, along with oth er relevant new clinical data as they are published, said company spokeswoman Elizabeth Sell, Philadelphia.
[Study included ThinPrep, SurePath, Hybrid Capture 2
According to international guidelines (4) for validation of hrHPV DNA tests, candidate assays should demonstrate clinical noninferiority to an established and clinically validated reference assay, such as Hybrid Capture 2
(HC2; Qiagen, Valencia, California) or [GP5.sup.+]/[6.sup.+] polymerase chain reaction (PCR).
Comparison of clinical and analytical performance of the Abbott RealTime High Risk HPV test and Hybrid Capture 2
in population-based cervical cancer screen-ing.
Participants were randomized to primary screening with the HPV DNA test (hybrid capture 2
) or to conventional cytology.
Agreement between the AMPLICOR human papillomavirus test and the hybrid capture 2
assay in detection of High-Risk Human Papillomavirus and Diagnosis of Biopsy-Confirmed High Grade Cervical Disease.
Aetna currently covers HPV DNA testing for patients with atypical squamous cells of undetermined significance using the Hybrid Capture 2