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IBMFSInherited Bone Marrow Failure Syndromes
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Alternatively, careful evaluation of the patient's history, physical examination, and family history may suggest an inherited BM failure syndrome (IBMFS) as the etiology.
Establishing the diagnosis of IBMFS vs acquired AA has significant therapeutic implications.
* Aplastic anemia can occur as a consequence of immune dysregulation and toxic exposures, and as a manifestation of several hematologic disorders, including myelodysplasia and IBMFS.