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Methods: Sixty patients with ICAE without any visible coronary stenosis were enrolled to this cross-sectional observational study.
However, LA passive emptying volume and LA passive emptying fraction were significantly decreased with ICAE patients (11.1 [+ or -] 3.2 vs.
Conclusion: Our study demonstrated presence of LA electrical and mechanical dysfunction in patients with ICAE. LA dysfunction may be associated with cardiac pathologies as arrhythmias, decrease in cardiac output and congestive failure.
Isolated coronary artery ectasia (ICAE) is one of the coronary artery anomalies, defined as the dilatation of the arterial segment to a diameter at least 1.5 times of that of the adjacent normal segment (1, 2).
Recently atrial conduction abnormalities in patients with ICAE was investigated as atrial electromechanical delay by TDI echocardiography (12) but the total atrial conduction time and atrial mechanical function have not been evaluated.
Previous studies have shown that oxidative stress, myocardial ischemia, increased sympathetic activity and high plasma levels of inflammatory markers are associated with ICAE (4-7).
Therefore, we aimed to assess the relationship between atrial electrical and mechanical functions in patients with ICAE.
The study population included 60 patients (36 men; mean age 51.1 [+ or -] 7.1 years) with ICAE. ICAE was defined as luminal dilatation of 1.5-fold to 2.0 fold of the adjacent normal coronary segment without significant obstructive lesions (13).
ICAE was defined as a dilatation of the arterial segment to a diameter at least 1.5 times or more as that of the adjacent normal artery or normal segments of the same vessel.
Em/Am ratio was significantly lower in patients with ICAE than controls (p=0.001).
PA-TDI duration was measured significantly higher in patients with ICAE than control group (p<0.001).
In the present study, we investigated that atrial electrical and mechanical function in patients with ICAE. We have demonstrated that Pmax and PWD and the PA-TDI duration were significantly related with ICAE.
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- Icahn, Carl C.