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ICAM1Intercellular Cell Adhesion Molecule-1
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These molecules include pro-inflammatory cytokines, such as IL-1, IL-6 and tumor necrosis factor alpha (TNF-[alfa]), clonal expansion and IL-2, subset of helper T lymphocytes (Th1), IL-12 and gamma Interferon (IFN-[gamma]) and, to a lesser extent, or subset Th2, IL-4 and IL-5, colony-stimulating factors such as granulocyte-macrophage colonystimulating factors (GM-CSF), chemokines as RANTES and MIP-1[alfa], adhesion molecules such as ICAM1, ELAM-1 and E-selectin, inflammatory mediators such as bradykinin, histamine, eicosanoids and nitric oxide, as well as molecules involved in the presentation of antigen and major histocompatibility complex (MHC) class II.
Expression of ICAM1 and VCAM1 serum levels in rheumatoid arthritis clinical activity: association with genetic polymorphisms.
Significant negative correlations were observed between ICAM1 and macronutrient intake in the gymnasts but not the controls.
La presentacion de peptidos antigenicos por las DC implica una estrecha interaccion con las celulas T especificas de antigeno, mediadas por moleculas como LFA-1 e ICAM1 que forman un aro alrededor del receptor antigenico de las celulas T (TCR) y de las moleculas del CMH.
Ischemia increases neutrophil retention and worsens acute renal failure: Role of oxygen metabolites and ICAM1.
Estas moleculas incluyen citocinas proinflamatorias, tales como IL-1, IL-6 y factor de necrosis tumoral alfa (TNF-[alfa]), la expansion clonal y IL-2, subconjunto de linfocitos T auxiliares (Th1), IL-12 e interferon gama (IFN-[gamma]) y, en menor extension, el subconjunto Th2, IL-4 y IL-5, factores estimulantes de colonias, tales como los factores estimulantes de colonias de granulocitos y macrofagos (GM-CSF), las quimiocinas como RANTES y MIP-1 a, moleculas de adhesion tales como ICAM1, ELAM-1 y E-selectina, los mediadores inflamatorios tales como bradicinina, histamina, eicosanoides y oxido nitrico, bien como moleculas comprometidas en la presentacion de antigeno y complejo principal de histocompatibilidad (MHC) de clase II.
SERPINE1, ICAM1, F3, MMP3, CCL2, CXCL5, CXCL9, and VCAM1; and CD69, PLAU, PLAT, SELP, SELE, HLA-DRA, IL1 A, PLAUR, SAA1, TIMP2, CCL26, TGFB1, NR4A2, CSF1, and CXCL10: tissue remodeling during inflammation and angiogenesis
On the other hand, EGCG and L-theanine inhibited TNF-[alpha]-induced adhesion of U937 cells to endothelial cells and inhibited increases in ICAM1, CCL2 and VCAM1 expression.
E-selectin upregulates neutrophil CD1 1b and the ligand for ICAM1, the intracellular adhesion molecule 1 gene, enhancing firm leukocyte attachment and transendothelial migration.
Thus, genes involved in oxidative stress, such as heme oxygenase 1 (HMOX1), nitric oxide synthase 3 (NOS3), superoxide dismutase 2 (SOD2), and alpha polypeptide (CEBA); genes involved in inflammation, such as apolipoprotein E (APOE), tumor necrosis factor (TNF), and interleukin 6 (IL6); and genes involved in endothelial dysfunction, such as ICAM1, VCAM1, and sphingosine1-phosphate receptor 1 (S1PR1), may also modify cardiovascular effects of As exposure.
An increase in IL-1[beta] has been demonstrated to enhance ICAM1 and E-cadherin expression, TGF-pi production, endothelial cell permeability, mesangial and fibroblast-proliferation, and matrix synthesis and to alter glomerular hemodynamics (Brady 1994; Pfeilschifter et al.
Correlations were relatively high for CpG sites in three of four genes with CpG sites measured at two positions (CRAT, IFN-[gamma], and IL6), and for one of three pairs of CpG sites in ICAM1 (0.