ICP0Infected Cell Protein 0 (herpes simplex virus protein)
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PowderMed has produced a DNA Plasmid (pPJV7630), which encodes the ICP0, ICP4, ICP22 and ICP27 antigens that appear relatively early in the viral replication cycle of HSV2.
The researchers also found that ICP0 exploits the same phosphorylation signal to bind to other cellular proteins in addition to RNF8, a hint that it may play a broader role in defeating antiviral defenses and manipulating cellular machinery.
Weitzman's study team was studying a viral protein called ICP0 that overcomes host defenses by targeting cellular proteins for destruction.