For more information about IEED
programs and services, visit the Indian Affairs website at http://www.
In addition, treatment options are available for managing many of the distressing symptoms associated with ALS, including spasticity, excess saliva, cramping, sleep disturbances, anxiety and depression, and IEED
(Andersen et al.
The hallmark of IEED is episodes of crying or laughing that are unrelated to or out of proportion with the eliciting stimulus.
Emotional outbursts in IEED are involuntary, episodic, and incongruent with baseline mood.
Disorders of affect--which IEED appears to be--involve impairment of the moment-to-moment regulation of emotion.
Although the prevalence of IEED is likely to be underestimated, approximately 1 million cases exist in the United States (Schiffer & Pope).
The prevalence of IEED is underestimated because this disease is often confused with other mood or affective disorders, such as major depressive disorder (Arciniegas et al.
Announced that based on a meeting with the FDA, the Company will conduct an additional Zenvia trial in patients with IEED
to confirm that a proposed lower dose is safe and effective.
Data were presented from patients with IEED, secondary to various neurologic diseases or injuries, treated with Zenvia for 52 weeks or longer.
In this open-label, multi-center study, 506 IEED patients with multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's dementia, Parkinson's disease, or injuries such as stroke and traumatic brain injury, were enrolled to evaluate long-term safety and tolerability with 321 patients completing more than six months of treatment.
As previously stated, the company plans on initiating a confirmatory clinical trial in IEED
with a new, lower quinidine dose formulation later this year," he added.
His contributions to the company have been meaningful, and the board anticipates that Keith will continue to show his considerable leadership skills as he navigates the company toward the anticipated eventual approval of Zenvia for IEED
and minimizes operating expenses during this time.