can occur in neurological conditions such as stroke, traumatic brain injury, amyotrophic lateral sclerosis, multiple sclerosis, seizure disorders, multiple system atrophy, corticobasal degeneration, and Alzheimer's disease.
For more information about IEED
programs and services, visit the Indian Affairs website at http://www.
In addition, treatment options are available for managing many of the distressing symptoms associated with ALS, including spasticity, excess saliva, cramping, sleep disturbances, anxiety and depression, and IEED
(Andersen et al.
The hallmark of IEED
is episodes of crying or laughing that are unrelated to or out of proportion with the eliciting stimulus.
occurs when affective motor control becomes disinhibited as a result of brain damage from neurologic disease or injury.
Although the prevalence of IEED
is likely to be underestimated, approximately 1 million cases exist in the United States (Schiffer & Pope).
was introduced as an inclusive term, replacing previous nomenclature such as pathologic laughing and crying, pseudobulbar affect, affective lability, and emotional incontinence.
In October 2006, the Company received an approvable letter for the treatment of Zenvia in IEED
The Company is targeting an annual net cash burn of $20 million, or an average of $5 million per quarter, inclusive of the projected costs for our planned confirmatory Phase III trial of Zenvia for IEED
but excluding any costs associated with a second Phase III Zenvia trial in DPN pain.
with neurologic diseases or injuries known to cause IEED
, or their caregivers, were surveyed to determine the prevalence of IEED
Food and Drug Administration (FDA) in late February 2007, that AVANIR will conduct an additional trial in patients with IEED
to confirm that a proposed lower does is safe and effective.
As previously stated, the company plans on initiating a confirmatory clinical trial in IEED
with a new, lower quinidine dose formulation later this year," he added.