Aden et al., "Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3
) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress," The Journal of Biological Chemistry, vol.
Several genes involved in apoptosis and/or in apoptosis regulation were modulated in BD samples including myeloid cell leukemia sequence 1 (BCL2-related), MCL-1, BCL2-like 11, BCL2L11, immediate early response 3, IER3
and ZFP36 ring finger protein-like 2, and ZFP36L2.
Neupane et al., "Dysregulated IER3
expression is associated with enhanced apoptosis in titin-based dilated cardiomyopathy," International Journal of Molecular Sciences, vol.
Pattern 3 included 15 genes that were induced only at 2 hr, including immediate early-response genes IER3
and IER5 and a p16 (INK4A) antagonist SEL1.