IEUBKIntegrated Exposure Uptake Biokinetic Model for Lead in Children (US EPA)
IEUBKIntegrated Exposure, Uptake and Biokinetic (lead exposure model; US EPA)
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The general consensus of a 1999 workshop was that a fully probabilistic version of the IEUBK model would aid in understanding how exposure variability affects the distribution of BLL (NRC 2005, p.
Regression equations derived from IEUBK were applied to convert absorbed dose (uptake) to BLL.
EPA estimates lead risk in children using the IEUBK model (3).
The potential effects of Zn on gastrointestinal uptake of Pb are of interest because risk assessment for Pb involves use of the IEUBK model for lead in children (2,3).
User's guide for the integrated exposure uptake biokinetic model for lead in children (IEUBK) (EPA 540-K-01-005).
Remedial Action Goal and Risk-based Cleanup Level Using IEUBK
In order to derive the cleanup level for this risk-based remedial action goal, we applied the IEUBK model (Hogan et al.
Several combinations of variables, including neighborhood soil means using radii of 200 ft, 500 ft, and 1,000 ft and age- and year-specific soil and dust categorical variables (i.e., grouped by both age and calendar year), were alternatively added, and model fit was evaluated by five criteria: a) convergence, b) chi-square probability test (p > 0.05), c) goodness of fit index (GFI) (> 0.90), d) parameters with significant t-statistics (p < 0.05), and e) parameter performance in subsequent IEUBK model analyses, described below (Carey 1998; SAS Institute Inc.
He points to his own unpublished research indicating that less than 5-10% of the lead in urban garden soil is bioavailable, compared with the 30% assumed by the IEUBK model.
EPA's IEUBK model and ALM, which predict BLLs expected as a consequence of environmental lead exposure.
These exploratory uses of the IEUBK are meant only to indicate the types of concentration values and changes in physiochemical parameters that might provide a mechanistic explanation for the correlations observed in this work.