IFABPIntestinal Fatty Acid Binding Protein
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Both CQCQD and carbachol protected the colonic damage shown by the reduction of overall colonic histopathology score (mean score of 1 and 0.1 versus 9.4, both P < 0.05; Figure 2(b)) and significantly reduced VIP and SP (all P < 0.05), with a trend towards decreasing iFABP (Figures 2(c)-2(f)).
In this study, it was shown that L-arginine-induced colonic damage with the increase of iFABP, VIP, and SP levels as well as decrease of MTL levels.
Indirect intestinal motility serum markers: (c) intestinal fatty acid binding protein (iFABP), (d) vasoactive intestinal peptide (VIP).
The level of IFABP and CRP were significantly higher in PI-IBS group than those in Non-PI-IBS group (pless than 0.05).
KEY WORDS: Post-infectious irritable bowel syndrome (PI-IBS), None post-infectious irritable bowel syndrome (NPI-IBS), Intestinal fatty acid binding protein (IFABP), Self-rating anxiety scale (SAS), Gastrointestinal symptom rating scale (GSRS).
Intestinal fatty acid binding protein (IFABP) is a 15-kDa cytoplasmic protein located in small intestinal enterocytes involved in the uptake and transport of polar lipids such as fatty acids from the small-bowel lumen, which has been associated with injury to the intestinal mucosa and injury common to inflammatory bowel diseases.6 When the integrity of the enterocyte membrane is compromised, I-FABP are rapidly released into the circulation.
Using a prospective observational study of fifty patients with severe sepsis, Zhu found the IFABP concentrations in all patients were significantly increased.8 In addition, C-reactive protein (CRP) is an inflammation marker, confirmed by many studies.
In addition, a blood sample was collected from all patients to detect the level of C-reactive protein (CRP) and intestinal fatty acid binding protein (IFABP).
The difference in age, CRP, IFABP, GSRS and SAS were compared by the Student's t-test.
No crossreactivity was found with recombinant human AFABP (Biovendor), IFABP (R&D Systems), LFABP (Abnova), or other related proteins: leptin, leptin receptor, adiponectin, resistin, and RELM-(3 at 100 [micro]g/L and IL-6 at 2 [micro]g/L (all provided by Biovendor).