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IFNgInterferon, Gamma
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A previous study demonstrated that both AMR and TCMR manifested strong expressions of IFNG [33].
18 gene specific primers (TLR2, NFKB1, IL2, IL16, TNF, IFNG, CXCR3, CCL1, CD81, CD84, RPS6KB2, STK17B, PRKCB1, MCL1, EEF1G, NFATC4, EEF1 and IER5) were used for real time expression profiling (24) (Table 1).
Subcutaneous interferon beta-1b acts as an anti-inflammatory and has several mechanisms of action, including a reduction in the production of pro-inflammatory IFNg and TNFa, inhibition of T-cell activation and clonal expansion, modulation of cytokine and matrix metalloproteinase production and the release and inhibition of T-cell migration and entry into the CNS.
More recently, Wang et al., using single-nucleotide polymorphism analysis, identified the IFNG (interferon, gamma), TMC6 (transmembrane channel-like 6; previously known as EVER1), and TMC8 (transmembrane channel-like 8; previously known as EVER2) genes to be associated with progression to cervical cancer (10).
The network encompassed 10 from 11 proteins closely connected through four major nodes: ubiquitin C (UBC), tumor necrosis factor (TNF), transforming growth factor beta 1 (TGFB1), and interferon gamma (IFNG) (Figure 3).
When comparing the expression of pro-inflammatory and anti-inflammatory cytokines in placental tissue in the GM+ and GMgroups, an increase in the levels of pro-inflammatory cytokines (TNF, IFNg and IL1[beta]) was observed in the former.
IFNG polymorphisms are associated with gender differences in susceptibility to multiple sclerosis.
(2010) found that the T allele of the IFNG +874 gene protects against leprosy, specifically among those of African descent, which clearly demonstrates the need for further studies on the association between the susceptibility to leprosy and skin color/race [18].
Defective regulation of IFNg and IL-12 by endogenous IL-10 in progressive MS.