IGASIInvasive Group A Streptococcal Infections
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Of the 306 reported IGASI cases, 112 (37%) were soft-tissue infections, 84 (28%) bacteremia, 32 (10%) pneumonia, and 29 (10%) STSS.
The death ratio from IGASI was 15% (42 deaths among 306 cases).
In our study, we identified 25 factors to be significantly associated with specific IGASI manifestations.
IGASI and STSS may be increasing in both incidence and severity (4).
To the best of our knowledge, no research has been published on transmission rates for the different clinical manifestations of IGASI. However, the primary mode of person-to-person transmission of S.
Even though IGASI is a reportable disease, our results for pneumonia may be an underestimate of the true values.
With regard to the generalizability of our results, when comparing our findings with previously published studies, we did not detect any geographic differences in the incidence of IGASI (17).
Having varicella before IGASI increased the risk of developing a soft-tissue infection 6 times and the risk of dying 5 times.
Our descriptive analysis appears to support previous research findings that those <1 year of age and those 260 years of age have the highest incidence of IGASI (3,21-23).
Our study finding that M1 and M3 accounted for >30% of all isolates tested for M surface proteins was consistent with previous studies that reported these 2 M serotypes as the most common for IGASI (3,15,16,23,24).