IGF-1Insulin-Like Growth Factor 1 (also seen as IGFI)
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These rats also had a "catch-up" phase of liver development after birth, characterized by increased levels of IGF-1.
IGF-1 as a member of growth factor family can promote the regeneration of collagenous fiber in intercellular substance components and the stablization of bone trabecula structure.9 ET-1, an relevant indicator of peroxidation damage, can promote the decomposition of collagenous fiber and cytoskeletal structure and the loss of sclerotin or calcium salt.10 In order to further reveal the relationship between different biological factors and patients' disease condition, this study analyzed the changes of serum levels of IGF-1 and ET-1 in patients with osteoporosis who were treated in our hospital and explored their relationships with cytokines and bone density.
Bone growth is both locally and systemically regulated by IGF-1, a hormonal mediator of growth hormone (GH).
Previous studies have shown that IGF-1 can help regenerate cartilage in animals.
IGF-1 is a growth factor that is particularly important in early development, Nunney explained, but IGF-1 has also been linked to a higher rate of cell division in tall adults.
In the central nervous system, IGF-1 is produced by both of the major types of brain cells neurons and glia.
Subculturing was performed when the fibroblasts reached about 70% to 80% of the bottle and the skin cells were treated with MT, FGF5, and IGF-1. The concentrations of MT used were 1 g/L, 0.2 g/L, 0.02 g/L; FGF5 were [10.sup.-4] g/L, [10.sup.-5] g/L, [10.sup.- 6] g/L; and IGF were [10.sup.-4] g/L, [10.sup.-5] g/L, [10.sup.-6] g/L the cells for 24 h, 48 h, and 72 h.
This characteristic has been explained in part by the absence of binding sites in IRS-4 for the tyrosine phosphatase SHP-2, an enzyme that mediates the inhibitory feedback loop necessary in normal cell cycle regulation by IGF-1 [12].
IGF-1 is lower in nondiabetic controls in spite of elevated GH [6-10].
Lee, "IGF-1 potentiation of IL-4-induced CD23/FceRII expression in human B cells," Molecules and Cells, vol.
Kruskal-Wallis test followed by Dunn's multiple comparison test were used to compare IGF-1 levels between early JIA, established JIA, and controls.