IGF-2Insulin-Like Growth Factor 2
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Genotyping for the IGF-2 Apal gene polymorphism (rs680) was performed by PCR with the use of specific published primers.
IGF-2 is expressed abundantly in the developing skeletal muscle and is a major factor for muscle growth, differentiation, and regeneration [22].
Because of their structural and functional homology with insulin all former names are now replaced by the term insulin-like growth factors, more precisely, insulinlike growth factor 1 (IGF-1) and insulin-like growth factor 2 (IGF-2).
Lamonerie, T., et al., "IGF-2 Autcorine Stimulation in Tumorigenic Clones of a Human Colon-Carcinoma Line," Int.
The insulin-like growth factors (IGFs, IGF-1 and IGF-2) can promote and stimulate stem cell differentiation towards several lineages from all three germ layers [22-26], including osteoblast differentiation [27] and in vivo bone development [28, 29].
The endogenous ligands of IR include insulin, IGF-1, and IGF-2, but IGF-1R is activated only by IGF-1 and IGF-2 [24].
The other two genes, one encoding a protein called insulin-like growth factor 2 (Igf-2) and one encoding the Igf-2 receptor, showed just the opposite behavior.
The IGF family consists of two IGF ligands (IGF-1 and IGF-2), three cell surface receptors (IGF-1 and IGF-2 receptors and the insulin receptor), and six IGF binding proteins (IGFBPs) [1].