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IGF1RInsulin Growth Factor 1 Receptor
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References in periodicals archive ?
IGF1R inhibitors were shown to have a potential for combined approaches in patients with pediatric GIST and adult wild type GIST (38).
Let-7b-5p regulates proliferation and apoptosis in multiple myeloma by targeting IGF1R. Acta Biochim Biophys Sin (Shanghai) 2014;46(11):965-972.
Insulin-like growth factor 1 receptor (IGF1R) signaling, which regulates Osterix (SP7), and RUNX2 are important factors in bone formation during development and in the postnatal organism [26-28].
We report the dramatic response to growth hormone therapy in this patient which highlights the importance of identifying patients with IGF1R deletion and treating them early.
Cell treatment with 1 mg/mL of the four different mixtures or with 100 nM insulin caused a significant increase in the phosphorylated isoforms of IGF1R, PI3K, and Akt, indicating a common pathway in insulin and steviol glycoside signaling mechanisms.
Apart from this, miR-378 promotes cardiomyocyte apoptosis by blocking a survival signaling cascade activated by Akt pathway through inhibition of expression of insulin-like growth factor 1 receptor (IGF1R) [100].
Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles.
(10) Cani et al (52) reported that p53, RB1, and NF1 mutations and EGFR (52,53) and IGF1R gene amplifications were detected in only the malignant tumors.
We first selected the 36 most important biological modules (CDK4, CDK6, CDK2AP2, BC[L.SUB.2], XIAP, BAX, CASP3, CASP8, CASP9, FOXA2, HNF4A, EBP, HGF, NFKB2, STAT3, IL6, I[L.SUB.1]0, HIF1AN, MYC, GSK3B, TP53, PTEN, RB1, MDM2, PDGFRA, SOX2, PIK3CA, FGFR1, IGF1R, EPHA2, MET, EGFR, DDR2, KEAP1, KRAS, and AKT1) out of the whole genome for lung cancer according to [36].
Association of polymorphisms and haplotypes in the insulin-like growth factor 1 receptor (IGF1R) gene with the risk of breast cancer in Korean women.
Speed highlighted AR as a biomarker included in the multi-protein quantitation panel with EGFR, HER2, HER3, IGF1R, MET, PD-L1, and ROS1.