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IGFBP-1Insulin-like Growth Factor Binding Protein-1
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References in periodicals archive ?
Gupta, "Hypoxia increases IGFBP-1 phosphorylation mediated by mTOR inhibition," Molecular Endocrinology, vol.
On excluding glycemic markers (glucose, Hb[A.sub.1c], and fructosamine) and insulin from consideration, 5 markers were identified as most informative: leptin, IL-18, GPT, IGFBP-1, and ACE.
(2002) Effect of diet and exercise on serum insulin, IGF-I, and IGFBP-1 levels and growth of LNCaP cells in vitro.
Among these, an induction of IGFBP-1 (Affymetrix probe set ID M58634_at) and aflatoxin B1 aldehyde reductase (Affymetrix ID AF045464_s_at), as well as the downregulation of retinol dehydrogenase type 2 (Affymetrix ID U33500_g_at) were observed.
The concentrations of IGF-I, IGF-mRNA, IGFBP-3 and IGFBP-1 in the liver and blood were measured via the analytical methods described below.
The [DLK-1.sup.+] fetal liver subpopulation as described by Chou and Lodish expressed various haematopoietic growth factors, such as insulin-like growth factor-2 (IGF-2), insulin-like growth factor binding protein-1 (IGFBP-1), thrombopoietin (THPO), angiopoetin like-3 (ANGPTL-3), stem cell factor (SCF), and stromal-derived factor-1 (SDF-1).
ALS has a high affinity for binary complexes of IGFs and IGFBP-3, but no affinity for free IGFs and IGFBP-1, -2, -4 or -6 (Baxter et al., 1989; Twigg and Baxter, 1998; Twigg et al., 1998), and low affinity for free IGFBP-3 (Baxter and Martin, 1989; Barreca et al., 1995; Lee and Rechler, 1995a).
Foxo1 cause lipid metabolism through induction of G6Pase, apoC-III, and Igfbp-1 expression (Nakae et al., 2001; Nakae et al., 2002; Altomonte et al., 2004).
Ninety-five percent of circulating IGF-I is bound to binding proteins (IGFBP-1 to -6), predominantly IGFBP-3, which modulate its actions and bioavailability (22, 30).
In part, this may be related to a marked increase in IGFBP-1. Nutrient intake and insulin status both determine serum IGFBP-1 concentrations and the extent of phosphorylation of IGFBP-1, which in turn determines IGF-binding affinity (25).
In order to detect the effects of different IGFBP-1 genotypes on production performance traits, we also investigated one population family of Lantang x Landrace (n = 172, gifted by Professor Chen Yaosheng, SCAU, China).
IGFBP-1, synonymous with placental protein-12 [10] and the pregnancy-associated endometrial al-globulin [11], is a 25-kDa protein expressed and secreted by hepatocytes, ovarian granulosa cells, and decidualized endometrium [12-16].