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Novel application of IGF-1 and IGFBP-3 generation tests in the diagnosis of growth hormone axis disturbances in children with beta-thalassaemia.
(2005) observed, in young adult soccer players (19 years of age), that soccer training decreased exercise-stimulated GH levels throughout the competitive season, but did not have any effect on basal IGF-1 and IGFBP-3 levels.
As far as biochemical parameters are concerned, GHD is characterized by low-circulating GH and IGF-I levels, and IGF-II, IGFBP-3, and ALS reduction, reflecting their GH-dependent status .
Pollak et al., "Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke," Journal of Clinical Endocrinology and Metabolism, vol.
Stolzenberg-Solomon, "Serum IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 molar ratio and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial," Cancer Epidemiology Biomarkers and Prevention, vol.
This prospective study aimed to determine the levels of IGF-1 and IGFBP-3 both intranodular and in the serum of patients with nodules in the thyroid gland who were planned to undergo biopsy, to investigate the relationship between expression of IGF-1 and thyroid nodule, and to evaluate the role of IGF-1 in differential diagnosis and pathogenetic function of benign and malignant thyroid nodules.
In glial cell lines, HN binding to IGFBP-3 blocks IGFBP-3-mediated apoptosis.
ELISA kits to detect alkaline phosphatase (ALP) activity and the concentrations of estradiol, osteocalcin, IGF-1, IGFBP-3, luteinizing hormone (LH), and follicle stimulating hormone (FSH) were purchased from R&D Systems (Minneapolis, USA).
Hankinson, "Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth hormone and breast cancer risk in The Nurses Health Study II," Endocrine-Related Cancer, vol.
Resultados: Os estudos utilizaram marcadores bioquimicos como: GDF-15, ST-2, NT-proBNP, IL-6, IGF-1, IGFBP-3, niveis de testosterona salivar e niveis de cortisol salivar e dados fisicos como: medidas antropometricas e testes de agilidade e questionarios especificos sobre ET, que avaliaram mudancas de carater subjetivas como: fadiga, falta de energia e autorregulacao.
Moreover, they identified insulin-like growth factor-binding protein-3 (IGFBP-3) as a novel mediator of apoptotic pathways in ARDS.
The researchers believed this to be caused by the increase in an important IGF-1 binding protein, IGFBP-3 (IGF binding protein-3), which has been documented as an inhibitor of cell growth and inducer of apoptosis.
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- IGF-binding protein 9
- IGF-binding protein 9
- IGF-I receptor
- IGF-II receptor
- IGFBP-related protein 10