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IGFBP1Insulin-like Growth Factor Binding Protein 1
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Because IGFBP1 levels were variable among individuals with a varying glucose tolerance, we excluded the patients with diabetes and impaired glucose tolerance.
Kato, "High concentrations of pyridoxal stimulate the expression of IGFBP1 in HepG2 cells through upregulation of the ERK/c-Jun pathway," Molecular Medicine Reports, vol.
In parallel, the liver changes of expression of CaBP9k and IGFBP1 had been established as estrogenic response markers, although the overall response was by far lower than the one detectable for CaBP9k or C3 in the uterus.
A decrease in IGF-1 and an increase in IGFBP1 in arsenic-exposed livers are similar to findings with the nongenotoxic model carcinogens such as oxazepam and Wyeth-14,643 (Iida et al.
The main secretory product of a pregnant woman's decidualized endometrium is insulin-like growth factor binding protein-1 (IGFBP1).
Accordingly, an adipogenic inhibitory function based on DLK-1 alone in USSC is unlikely, although a functional interaction with other factors, such as IGFBP1, needs to be analyzed.
Plasma GH levels are raised in type 1 diabetic patients with poor glycemic control, while the concentration of IGF-1 is low and that of IGF binding protein (IGFBP1), a modulator of its activity is raised.
Genes induced by P4 and further stimulated by IFNT in uterine LE/sGE include: i) morphogens (GRP, IRF6); ii) proteases (CTSL); iii) protease inhibitors (CST3); iv) mediators of cell migration and adhesion including SPP1, galectin 15 (LGALS15), periostin (POSTN) and insulin-like growth factor binding protein 1 (IGFBP1); v) hypoxia inducible factors (HIF1A and HI[F.sub.2[alpha]]) that stimulate angiogenesis and erythropoiesis; vi) hydroxysteroid dehydrogenase 11B (HSD11B1) that mediates corticosterone metabolism and expression of glucocorticoid recetors (GCCR); vii) synthesis of prostaglandins (PTGS2) ; and viii) IRF2 a potent repressor of transcription (Bazer et al., 2009; Bazer et al., 2010; Bazer et al., 2011a).
Analyses of umbilical cord blood after complicated deliveries have shown low levels of insulin-like growth factor I (IGF-I) and insulin, but elevated levels of insulin-like growth factor binding protein 1 (IGFBP1) and interleukin-6 (IL-6) (28).
Besides Cyp1a2, the gene exhibiting the greatest downregulation was Igfbp1 (insulin-like growth factor binding protein-l), showing only 12% expression of that in the Cyp1a2(+/+) wild-type liver.