IGFR2Immunoglobulin G Fc Receptor II
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Further, work from our laboratory demonstrated that in vitro hypoxia can cause LC cells to produce genes involved in ECM production and remodelling including insulin-like growth factor 2 receptor (IGFR2) and macrophage migration inhibitory factor 1 (MIF) (Figure 4).
IGFR2 does not have intracytoplasmatic signaling domain and is thought to be recycled between the plasma and different cellular compartments.
Yet abnormal activity of the IGFR2 genes may not be the only factor contributing to large-offspring syndrome.