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Virus-bound IgA Ab titer in BALF from the mice treated with maoto extract (0.8 and 1.3 g/kg/day) also increased significantly (Figure 5(c)), and virus-bound IgGj Ab titer in serum from the mice treated with maoto extract (0.8 g/kg/day) also significantly increased compared with water-treated group at 52 hours p.i.
The effect of maoto extract against influenza virus infection in A/J mice was shown as the antipyretic action (Figure 3), decreased virus replication in the bronchoalveolar and nasal cavities (Figure 4), and augmenting influenza virus-bound IgA Ab in BaLF, IgGj Ab in serum, and IgM and IgA Abs in NLF (Figure 5) on the virus-infected mice at 52 hours p.i.
Analysis was performed with an Immage instrument (Beckman-Coulter) for the following 22 analytes: albumin, prealbumin (PAB), [[alpha].sub.1]-acid glycoprotein, al-antitrypsin, [[alpha].sub.2] macroglobulin (AMG), ([[beta].sub.2] microglobulin, factor B, C1 inhibitor, C1q, C3, C4, C5, ceruloplasmin (CERU), IgA, IgG, IgGj, IgGz, IgG3, Ig[G.sub.4], IgM, and [kappa] and [lambda] light chains.