IGKCImmunoglobulin Kappa Constant Region
IGKCInternational Goodwill Kendo Club (martial arts)
IGKCIllinois Gamma Knife Center (Elk Grove Viillage, IL)
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The IGK locus is deleted through the kappa deleting element (Kde) and two different types of Kde recombination can inactivate nonfunctional IGK rearrangements: Kde rearranges to the intron RSS resulting in the deletion of the IGKC gene and the maintenance of the IGKV-J junction (9,10).
The qPCR primers and hydrolysis probes for the genes CALM2 [calmodulin 2 (phosphorylase kinase, delta)], CHPT1 (choline phosphotransferase 1), CXCL13 [chemokine (C-X-Cmotif) ligand 13], ERBB2 [v-erbb2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)], ESR1 (estrogen receptor 1), IGKC (immunoglobulin kappa constant), MLPH (melanophilin), MMP1 [matrix metallopeptidase 1 (interstitial collagenase)], OAZ1 (ornithine decarboxylase antizyme 1), PGR (progesterone receptor), RAC-GAP1 (Rac GTPase activating protein 1), RPL37A, TOP2A [topoisomerase (DNA) II alpha 170kDa], and UBE2C (ubiquitin-conjugating enzyme E2C) were identified with Primer Express[TM] software (Applied Biosystems) according to the manufacturer's instructions.
The human [kappa] light chain constant domain (IGKC) was amplified using one PCR primer containing an XbaI site and another primer containing an SgfI site (GAT CTC TAG ACT AAC ACT CTC CCC TGT TGA AGC and GAT CGC GAT CG C AC G AAC TGT GGC T GC ACC ATC T GT C).