IIPGAInternational Inflatable Products and Games Association
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+4860 A>C was the only exonic SNP found within IL18 by IIPGA; however, it is nonsynonymous-no other potentially functional SNPs were found.
Because both are studies of whites, however, it can be deduced, with IIPGA IL18 resequencing (http://innateimmunity.net/), that hGTATA marks the same haplotype previously found to be associated with lower IL-18 concentrations and a protective effect on risk.
[6] Nonstandard abbreviations: IL, interleukin; IL-18BP, IL-18 binding protein; CHD, coronary heart disease; CUDAS, Carotid Ultrasound Disease Assessment Study; CUPID, Carotid Ultrasound in Patients with Ischaemic Heart Disease; IMT, intima-media thickness; IIPGA, Innate Immunity PGA; IMT, intima-medial wall thickness; tSNP, tagging single-nucleotide polymorphism; SNP, single-nucleotide polymorphism; HWE, Hardy-Weinberg equilibrium; LD, linkage disequilibrium; hGTATA, GTATA haplotype; hTTATC, TTATC haplotype.