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Related to IL-6: IL-1b, IL-8
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To discern the IL-6 trends, the researchers obtained at least two blood samples annually from 119 caregivers and from 106 people with healthy spouses or who were widowed, separated, divorced, or never married.
Proinflammatory cytokine IL-6 is closely linked with pathology in a wide range of diseases and conditions that have an inflammatory basis.
Clotted blood samples were centrifuged at 15208 for 10 min, then separated and frozen at -70 [degrees]C until IL-6 concentrations were measured in duplicate by a highly sensitive ELISA (Quantakine HS; R & D systems, Minneapolis, MN).
The report includes a compilation of currently active projects in research and development of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) antagonists.
The cytokine IL-6 has also been implicated in blocking insulin action.
We determined TNF-[Alpha], IL-1[Beta], IL-6, IFN-[Gamma], IL-2, IL-4, and IL-10 secretions in serum and in BAL fluid according to the manufacturer's procedure using commercial ELISA kits from BioSource (Camarillo, CA).
Our standard assays for both IL-10 and IL-6 already are high demand products," said Jim Chamberlain, president and CEO of BioSource.
Louis, who has studied fat's IL-6 production in people, also argues that the excess CRP in obese individuals "may stem from their having more fat tissue, not inflammation.
A genetically engineered molecule developed by Ares-Serono, IL-6 is showing promise in the treatment of blood platelet deficiency (thrombocytopenia), a condition frequently resulting from chemotherapy and radiotherapy in cancer treatment.
We've shown that these three factors are interrelated, but we can't say for sure that increases in IL-6 concentration precede cold symptoms.
Christine Cegelis, Democratic Candidate for Congress, IL-6