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Nevertheless a summary of cytokine profiles in HSIL is: that there is increased expression of IL2R, IL4, TGF[beta] and ILl0 but decreased expression of IL2 and IFN[gamma] reflecting an immunoregulatory milieu.
However, in their study, only S100A4 expression correlated with the ability to form liver metastases, as evaluated in a quantitative model of metastasis in NOG (NOD/Shi-scid IL2r [gamma] null) mice.
In this group, social QoL was also negatively associated with %HLA-DR+ in T cells (r = -.245) and mitogen stimulated T cell function (IL2R expression on T cells after 72 h incubation with PHA; r = -.243).
Immulite IL2R. Los Angeles, CA: Diagnostics Products Corporation, 2002.
De-carboxy prothrombin or PIVKA-II (Protein Induced in Vitamin K Absence--factor II) was measured by ELISA (Asserachrom PIVKA-II, Diagnostica Stago, Asnieres, France), interleukin-2 receptor (IL2r) by endpoint ELISA (Milenia kit, DPC, Los Angeles, USA) and IGF-1 by ELISA using a non-extraction procedure (Diagnostic Systems Laboratories, Webster, Texas, USA).
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- IL1RA, CD121 antigen-like family member A
- IL35 subunit