Unlike mass brands, ILNP bottles are housed in matte black cartons embellished with silver foil text and a die-cut heart that perfectly frames the polish colorway inside.
Once shipped to mail order consumers in standard-issue bubble mailers, ILNP polishes now ship in sturdy cardboard mailers fitted with rugged black thermoformed trays that protect individual bottles from breakage during shipping.
ILNP currently sells only through its online website, Etsy and Amazon.
In cultured liver cells, ApoE enhanced both the cellular uptake and silencing activity of siRNAs formulated in iLNPs
. In an ApoE knockout mouse model, iLNPs
demonstrated a complete loss of activity due to the absence of ApoE as an endogenous targeting ligand.